Derivatization reagents for GC, silylation, MBDSTFA

MBDSTFA (MTB-TFA or MTBSTFA) is a silylation reagent which donates a tert-butyldimethylsilyl group (TBDMS) for derivatizing active hydrogen atoms in hydroxyl, carboxyl and thiol groups, primary and secondary amines as well as amino acids. Fast reactions (typically 5–20 min) with high yields (> 96 %). By-products are neutral and volatile.TBDMS ethers are more stable than the corresponding TMS ethers. The chromatographic retention times are longer due to the large protecting group, which may improve some separations. Due to the high molecular ion concentration at M+-57 useful for GC-MS applications. These products contain harmful substances which must be specially labeled as hazardous.